Phase 3 of Singapore’s mega gene-mapping effort to enrol at least 400,000 patients

Phase 3 of Singapore’s mega gene-mapping effort to enrol at least 400,000 patients


SINGAPORE – Singapore has launched the third phase of its national programme to map genomes for preventive, personalised treatments, aiming to gather data from 400,000 to 450,000 patients recruited directly from healthcare settings.

Precision medicine is a targeted approach to disease treatment and prevention that takes into account individual differences in genes, environments and lifestyles.

Running from 2025 to 2031, phase three of the National Precision Medicine (NPM) programme will enrol patientswith a wide range of health conditions, enabling researchers to study how genetic, lifestyle and environmental factors interact in real-world clinical settings. 

This will deepen the understanding of disease progression, enabling them to tailor treatment and ultimately customise care for each patient. 

Having a large sample size will also help with the detection of rare diseases and less common genetic variants in the population.

“We must move from a system that reacts to illness to one that predicts and prevents it – and ultimately preserves health,” said Health Minister Ong Ye Kung on Nov 14 at the launch at Marina One West Tower.

“When the deep biological insights of genomics are combined with the predictive power of AI plus the policies of preventive care and population health, we transform the healthcare system in a very fundamental way,” he said.

“This is the foundation for a new kind of healthcare, one that not just treats illness and cures individual patients, but keeps people healthy for longer and is potentially more effective and sustainable even as our population ages.”

NPM is a multi-year, three-phase effort that started in 2017.



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