Singapore confirms two locally transmitted mpox cases; authorities say risk to public is low

The second case, a 34-year-old man, had reported recent travel history and sexual contact, and had “prolonged physical contact” with the first case recently, said CDA.

He developed symptoms on Mar 26 and sought medical care on Mar 31. On Apr 1, laboratory testing confirmed his infection.

He is similarly in stable condition and has been placed on home isolation until Apr 21, pending further clinical review.

“Investigations and contact tracing are ongoing for both cases. Their close contacts have been advised to monitor their health and seek medical care if they are unwell. High risk contacts will be recommended mpox vaccination as post-exposure prophylaxis,” said CDA.

According to data published on CDA’s website, there have been seven mpox cases so far, as compared to four cases for the entire 2025. To date, all mpox infections detected have been Clade IIb infections.

Clade 1 is the deadlier subtype of mpox. A mutated strain – clade 1b – first emerged in September 2023 and was first detected among sex workers in the Democratic Republic of Congo. It was behind a surge in cases in African countries in 2024.

Common mpox symptoms include rash, fever, headache, muscle aches, backache, and swollen lymph nodes.  

“Mpox is predominantly transmitted through intimate or prolonged physical contact, including sexual contact. Population-wide vaccination is therefore not recommended.”

The agency added that for groups at high risk of exposure, the mpox vaccine is available on a self-paid basis, at the Department of Sexually Transmitted Infections Control Clinic, Tanjong Pagar Medical Clinic, Dr Jay Medical Centre, and Anteh Dispensary.

It will also be available at the National Centre for Infectious Diseases from May 2026 onwards. 

“The public should remain vigilant and protect themselves from mpox by avoiding high-risk sexual activities, such as engaging in casual sex or having multiple sexual partners.

“In addition, travellers to countries affected by mpox should practise good hand hygiene, reduce physical contact with persons who are unwell and avoid consumption of bushmeat.”