\n<\/p>\n
As for stacking a GLP-1 RA with other weight-loss medications, it is done at some obesity clinics in Singapore but there is no large, randomised trial to support the practice, according to Dr Yeo. \u201cCombination therapy is used in a few narrow situations, after a proper trial of one drug, but not at the first visit.\u201d<\/p>\n
Such situations may include a p<\/span>artial response, where the patient has lost some weight on a tolerated GLP-1 RA dose but is short of the target. \u201cAnd the dose cannot be pushed higher because of the side effects or cost,\u201d explained Dr Yeo.<\/p>\n Another scenario for combination therapy is weight-loss plateau. \u201cThe patient\u2019s weight has been stable for about three months on a maximal tolerated dose,\u201d listed Dr Yeo. \u201cAdherence and diet have been checked, and surgery has been declined.\u201d<\/p>\n Conversely, there are also patients who haven\u2019t opted for GLP-1 RA medications, he said. \u201cThe patient\u2019s target weight as well as usage duration are considerations. If it is just for short term use, phentermines or orlistat can be considered instead.\u201d Another factor is cost \u201cbecause GLP-1 RA tend to be more expensive\u201d, said Dr Yeo. A month’s supply of Ozempic shots, for instance, can cost around S$400 or more.<\/span><\/p>\n Whether injected or ingested, GLP-1 RAs can cause side effects, mainly gastrointestinal symptoms such as nausea, vomiting, bloating, constipation or diarrhoea, said Dr Ho. \u201cThese side effects are common. But they can be mitigated by gradual dose escalation and they usually improve over time.”<\/p>\n Even with those measures in place, Dr Ng highlighted that GLP-1 RA medications are not for everyone. \u201cWe are particularly cautious with people with previous pancreatitis, significant gastrointestinal disease, severe kidney or liver problems, pregnancy, and certain other medical conditions. The decision should, therefore, be made after a proper medical assessment.\u201d<\/span><\/p>\n<\/div>\nWHAT ABOUT THE SIDE EFFECTS?<\/h2>\n
\n
\n
Read Full Article At Source <\/a>
\n