{"id":87501,"date":"2026-09-24T14:01:01","date_gmt":"2026-09-24T06:01:01","guid":{"rendered":"https:\/\/sgbuzz.com\/?p=87501"},"modified":"2026-09-24T14:01:01","modified_gmt":"2026-09-24T06:01:01","slug":"singapore-to-develop-and-produce-new-mrna-vaccines","status":"publish","type":"post","link":"https:\/\/sgbuzz.com\/?p=87501","title":{"rendered":"Singapore to develop and produce new mRNA vaccines"},"content":{"rendered":"<p><br \/>\n<\/p>\n<div>\n<p class=\"text-primary article-summary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">SINGAPORE \u2013 <!-- -->Singapore is looking at supporting the development and production of new mRNA influenza vaccines here. This will greatly boost the nation\u2019s pandemic preparedness and is key to helping it exit the next deadly contagion, said Health Minister Ong Ye Kung.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">The Health Ministry hopes to work with the likes of medical research organisation Hilleman Laboratories &#8211; which has its headquarters and manufacturing facility in Singapore, to develop new mRNA vaccines.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">Messenger ribonucleic acid (mRNA) vaccines, which were first harnessed widely <a href=\"https:\/\/www.straitstimes.com\/opinion\/nobel-for-mrna-vaccine-shows-power-of-perseverance?ref=inline-article\" rel=\"noopener\" class=\"gap-x-04 items-center inline text-primary-60 select-auto\" aria-label=\"link\" target=\"_blank\" data-testid=\"custom-link\"><span class=\"inline font-tertiary-body-baseline-regular\" data-testid=\"typography-test-id\">in the fight against Covid-19<\/span><\/a>, played a critical role in curbing its spread.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">Such vaccines probably offer the greatest flexibility in development and time to market, Ong said in an interview with The Straits Times and Lianhe Zaobao.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">mRNA vaccine technology allows vaccines to be\u202f<a href=\"https:\/\/www.straitstimes.com\/singapore\/health\/making-of-a-speedy-covid-19-vaccine-using-science-to-make-the-body-a-factory?ref=inline-article\" rel=\"noopener\" class=\"gap-x-04 items-center inline text-primary-60 select-auto\" aria-label=\"link\" target=\"_blank\" data-testid=\"custom-link\"><span class=\"inline font-tertiary-body-baseline-regular\" data-testid=\"typography-test-id\">designed and produced more quickly<\/span><\/a> than traditional ones, making them a good option to combat a fast-spreading outbreak.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">\u201cI think it\u2019s useful to try out something that\u2019s mRNA platform, and you need to produce it for peacetime and keep the<!-- --> facility warm,\u201d<!-- --> he explained. \u201cSo let\u2019s produce a vaccine that is commonly <!-- -->used. Influenza<!-- --> is a possibility.\u201d<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">On pandemic preparedness, he said Singapore is \u201c50 per cent\u201d prepared and that \u201ca lot more important work needs to be done\u201d.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">Critically, this means building up vaccine manufacturing and development capability.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">\u201cI think it is the most important because when you have a Disease X kind of pathogen in the next pandemic, the only way for the world to exit it is to have an effective vaccine.\u201d<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">Disease X is the name given to <a href=\"https:\/\/www.straitstimes.com\/world\/what-is-disease-x-how-scientists-are-preparing-for-the-next-pandemic?ref=inline-article\" rel=\"noopener\" class=\"gap-x-04 items-center inline text-primary-60 select-auto\" aria-label=\"link\" target=\"_blank\" data-testid=\"custom-link\"><span class=\"inline font-tertiary-body-baseline-regular\" data-testid=\"typography-test-id\">a future epidemic caused by an unknown pathogen<\/span><\/a>.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">\u201cWith an effective vaccine, we can expect a similar experience to how we dealt with the Covid-19 outbreak \u2013 vaccinate, open up, then exit.\u201d<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">He pointed to Singapore-based vaccine research and development organisation Hilleman Laboratories\u2019 efforts in <a href=\"https:\/\/www.straitstimes.com\/singapore\/health\/spore-based-lab-to-produce-clinical-trial-doses-for-potential-new-ebola-vaccine?ref=inline-article\" rel=\"noopener\" class=\"gap-x-04 items-center inline text-primary-60 select-auto\" aria-label=\"link\" target=\"_blank\" data-testid=\"custom-link\"><span class=\"inline font-tertiary-body-baseline-regular\" data-testid=\"typography-test-id\">developing and producing vaccines against the rare Bundibugyo ebolavirus strain<\/span><\/a> spreading rapidly in the Democratic Republic of the Congo.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">\u201cI hope this effort with Hilleman brings us to 60 per cent. If we can produce an influenza mRNA vaccine, I think we move even closer,\u201d Ong added.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">He said that Hilleman\u2019s Singapore facility will produce material for early clinical trials, and if those succeed, its annual domestic production capacity could reach 12 million doses of drug product. Depending on needs, it will make arrangements for technology transfer to a larger-scale manufacturer in the region.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">\u201cThis is preparedness in action: existing science, an operating facility that is kept warm and trusted partners to scale up \u2013 all of which shorten the path from threat to a full response. It offers us a possible approach in response to Disease X in future,\u201d Ong<!-- --> said<!-- -->.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">But there is no such thing as being 100 per cent ready.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">Singapore will never be fully prepared to deal with a next Disease X, he cautioned. \u201cThere is always an unknown that you need to decide as and when things happen.\u201d<\/p>\n<p><iframe loading=\"lazy\" title=\"Pandemic threat: Is Singapore ready for the next big one?\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/vPivISXvOQA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">Ong said Singapore is placing a bet based on science: <!-- -->To<!-- --> deal with the next totally new virus, the most probable vaccine platform against it will be mRNA.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">\u201cIt offers the most flexible platform and fastest to market, fastest to develop, fastest to produce. And with AI technology, I think you can reiterate the solutions much faster,\u201d he added.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">Hilleman is a joint venture between MSD, the international trade name of American pharmaceutical giant Merck &amp; Co, and British charitable foundation Wellcome Trust. In 2021, it moved its headquarters to Singapore and its manufacturing facility was <a href=\"https:\/\/www.straitstimes.com\/singapore\/vaccine-maker-hilleman-opens-27m-plant-in-singapore-to-bolster-pandemic-preparedness?ref=inline-article\" rel=\"noopener\" class=\"gap-x-04 items-center inline text-primary-60 select-auto\" aria-label=\"link\" target=\"_blank\" data-testid=\"custom-link\"><span class=\"inline font-tertiary-body-baseline-regular\" data-testid=\"typography-test-id\">officially opened by Ong in November 2023<\/span><\/a>.<\/p>\n<figure class=\"landscape inline-media-wrapper\" data-testid=\"inline-media-test-id\">\n<div class=\"flex flex-col items-start relative w-fit\"><picture><source media=\"(max-width: 480px)\" srcset=\"https:\/\/cassette.sphdigital.com.sg\/image\/straitstimes\/378e0b553cfa9df20a29a0376868b3b8b685b79b4680ff07fe61abb84066df13?w=480\"\/><source media=\"(min-width: 481px) and (max-width: 720px)\" srcset=\"https:\/\/cassette.sphdigital.com.sg\/image\/straitstimes\/378e0b553cfa9df20a29a0376868b3b8b685b79b4680ff07fe61abb84066df13?w=720\"\/><source media=\"(min-width: 721px and max-width: 3999px)\" srcset=\"https:\/\/cassette.sphdigital.com.sg\/image\/straitstimes\/378e0b553cfa9df20a29a0376868b3b8b685b79b4680ff07fe61abb84066df13?w=900\"\/><source media=\"(min-width: 4000px)\" srcset=\"https:\/\/cassette.sphdigital.com.sg\/image\/straitstimes\/378e0b553cfa9df20a29a0376868b3b8b685b79b4680ff07fe61abb84066df13\"\/><img decoding=\"async\" src=\"https:\/\/cassette.sphdigital.com.sg\/image\/straitstimes\/378e0b553cfa9df20a29a0376868b3b8b685b79b4680ff07fe61abb84066df13\" alt=\"Health Minister Ong Ye Kung opened the Hilleman Laboratories\u2019 current Good Manufacturing Practice facility in 2023.\" class=\"aspect-landscape flex items-start shrink-0 object-cover landscape article-landscape mobile:w-auto tablet:w-auto\" data-testid=\"image-test-id\" loading=\"lazy\"\/><\/picture><\/div><figcaption class=\"mobile:mx-16 tablet:mx-00 pt-08 pb-16\">\n<p class=\"inline text-secondary font-secondary-captions-baseline-regular\" data-testid=\"inline-media-caption-test-id\">Health Minister Ong Ye Kung opened the Hilleman Laboratories\u2019 current Good Manufacturing Practice facility in 2023.<\/p>\n<p class=\"inline text-tertiary font-secondary-captions-baseline-regular\" data-testid=\"inline-media-credit-test-id\"> <!-- -->PHOTO: ST FILE<\/p>\n<\/figcaption><\/figure>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">On Sept 25, Ong, who is also Coordinating Minister for Social Policies, will attend the United Nations General Assembly High-Level Meeting in New York, the US.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">He also spoke at a side event on Sept 23 organised by his ministry and Hilleman, where he similarly touched on how Singapore is preparing to support the pilot initiative to develop an mRNA influenza vaccine here.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">\u201cIt serves a peacetime need, while building up our adaptable capability, and I hope Hilleman can support this,\u201d he said in his speech.<\/p>\n<figure class=\"default inline-media-wrapper\" data-testid=\"inline-media-test-id\">\n<div class=\"flex flex-col items-start relative w-fit\"><picture><source media=\"(max-width: 480px)\" srcset=\"https:\/\/cassette.sphdigital.com.sg\/image\/straitstimes\/e1aeb9f354ddc92f54c0032c0ef36b6c0f5bc415f1e48ea18862095014eb75b0?w=480\"\/><source media=\"(min-width: 481px) and (max-width: 720px)\" srcset=\"https:\/\/cassette.sphdigital.com.sg\/image\/straitstimes\/e1aeb9f354ddc92f54c0032c0ef36b6c0f5bc415f1e48ea18862095014eb75b0?w=720\"\/><source media=\"(min-width: 721px and max-width: 3999px)\" srcset=\"https:\/\/cassette.sphdigital.com.sg\/image\/straitstimes\/e1aeb9f354ddc92f54c0032c0ef36b6c0f5bc415f1e48ea18862095014eb75b0?w=900\"\/><source media=\"(min-width: 4000px)\" srcset=\"https:\/\/cassette.sphdigital.com.sg\/image\/straitstimes\/e1aeb9f354ddc92f54c0032c0ef36b6c0f5bc415f1e48ea18862095014eb75b0\"\/><img decoding=\"async\" src=\"https:\/\/cassette.sphdigital.com.sg\/image\/straitstimes\/e1aeb9f354ddc92f54c0032c0ef36b6c0f5bc415f1e48ea18862095014eb75b0\" alt=\"Health Minister Ong Ye Kung speaking at an event organised by his ministry and Hilleman on in New York Sept 23.\" class=\"aspect-default flex items-start shrink-0 object-cover default article-default mobile:w-auto tablet:w-auto\" data-testid=\"image-test-id\" loading=\"lazy\"\/><\/picture><\/div><figcaption class=\"mobile:mx-16 tablet:mx-00 pt-08 pb-16\">\n<p class=\"inline text-secondary font-secondary-captions-baseline-regular\" data-testid=\"inline-media-caption-test-id\">Health Minister Ong Ye Kung speaking at an event organised by his ministry and Hilleman Laboratories in New York on Sept 23.<\/p>\n<p class=\"inline text-tertiary font-secondary-captions-baseline-regular\" data-testid=\"inline-media-credit-test-id\"> <!-- -->PHOTO: MINISTRY OF HEALTH<\/p>\n<\/figcaption><\/figure>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">In addition, Singapore is working with companies with capabilities across vaccine platforms and manufacturing. These include Sanofi, GSK, Moderna and Thermo Fisher Scientific.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">The Republic is also exploring working with Wellcome Leap \u2013 the non-profit entity founded by Wellcome Trust \u2013 and the Coalition for Epidemic Preparedness Innovations (CEPI) to establish an RNA Readiness and Response (or R3) global biofoundry here, one of the few centres around the world.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">The biofoundry\u2019s model separates product development from production \u2013 an approach common in the semiconductor industry \u2013 and explores continuous-flow RNA manufacturing to reduce bottlenecks.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">Ong said in the interview that he believed that the way large pharmaceutical companies produce new vaccines would be different from the Covid-19 outbreak, where Pfizer, Moderna, Johnson &amp; Johnson and AstraZeneca all launched their own vaccines separately.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">When the next pandemic hits, <!-- -->he<!-- --> predicts that there will be a vaccine solution put forth by CEPI and its network of laboratories.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">CEPI, a global foundation based in Oslo, London and Washington that funds vaccine development, aims to develop safe and effective vaccines within 100 days of identifying a new pandemic threat.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\"><a href=\"https:\/\/www.straitstimes.com\/singapore\/health\/risk-of-another-pandemic-crisis-remains-ong-ye-kung?ref=inline-article\" rel=\"noopener\" class=\"gap-x-04 items-center inline text-primary-60 select-auto\" aria-label=\"link\" target=\"_blank\" data-testid=\"custom-link\"><span class=\"inline font-tertiary-body-baseline-regular\" data-testid=\"typography-test-id\">Singapore supports CEPI\u2019s efforts<\/span><\/a> through technical exchanges and research collaborations, as well as continued contributions to the coalition.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">With CEPI leading efforts in vaccine development, <!-- -->Ong said: \u201cWhat<!-- --> happens is the industry becomes more like the semiconductor industry. You have companies that just design the chip, like Nvidia, and you have got companies like TSMC that just produce the chip whatever the design is, and they are called f<!-- -->oundries.\u201d<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">The biofoundry\u2019s continuous-flow production model allows its production volume to be much larger, even though very little space is needed.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">Ong said:<!-- --> \u201cWe are talking about hundreds of millions or billions of doses a year. It is still very preliminary, but this is a project that we are working on as a biofoundry, and it will have the ability to produce mRNA vaccines.\u201d<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">Since Covid-19, Singapore has made several changes to prepare for the next outbreak.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">These include converting its community care facilities that housed Covid-19 patients to transitional care facilities and bringing private general practitioners into the public healthcare network; amending the Infectious Diseases Act; and setting up the Communicable Diseases Agency.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">Ong said these were the \u201cthree big pieces\u201d of local response, but two other pieces of international work were necessary too, as a pandemic will be an international event and a global threat.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">\u201cOne is global surveillance, so that when it pops up, we know in the first instance as early as possible. Second is to build up vaccine manufacturing and vaccine development<!-- --> capability,\u201d<!-- --> he added.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">As a small market, Singapore is able to host some of the world\u2019s most advanced vaccine manufacturing capability. \u201cThe vaccine manufacturer is quite assured that putting something in Singapore means most of its vaccines can be exported to the world and the region to help the world, and we wouldn\u2019t impose things like export control,\u201d Ong said.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">\u201cI mean, one week of production or maybe a few days of production is enough for the whole Singapore. The rest is for the region and the world&#8230; Singapore is a good place to put your investments and your capability, and that put us in a much more secure position.\u201d<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">Pointing to the next pandemic as an evolutionary certainty, he said at the MOH-Hilleman event: \u201cWe should remember that while a virus is biological, a pandemic is never only a medical event. It is also political, economic and social.<\/p>\n<p class=\"text-primary font-tertiary-body-baseline-regular\" data-testid=\"article-paragraph-annotation-test-id\">\u201cTo prepare for Disease X, we must resist denial, stigma, unfairness and the temptation to retreat behind national borders when global cooperation is most needed. Instead, we must harness the constructive power of our unity of purpose. We need to cooperate with each other, place our confidence in science and put in place overlapping and complementary plans ahead of time.\u201d<\/p>\n<\/div>\n<p><br \/>\n<center><br \/>\n<br \/><a href=\"https:\/\/www.straitstimes.com\/singapore\/health\/new-mrna-vaccines-to-be-developed-produced-in-spore-to-develop-expertise-prepare-for-disease-x\" target=\"_blank\" rel=\"noopener\">Read Full Article At Source <\/a><br \/>\n<center\/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>SINGAPORE \u2013 Singapore is looking at supporting the development and production of new mRNA influenza vaccines here. This will greatly boost the nation\u2019s pandemic preparedness&#8230;<\/p>\n","protected":false},"author":1,"featured_media":87503,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[2611],"tags":[],"class_list":["post-87501","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-buzz-headlines","wpcat-2611-id"],"brizy_media":[],"_links":{"self":[{"href":"https:\/\/sgbuzz.com\/index.php?rest_route=\/wp\/v2\/posts\/87501","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sgbuzz.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sgbuzz.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sgbuzz.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sgbuzz.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=87501"}],"version-history":[{"count":0,"href":"https:\/\/sgbuzz.com\/index.php?rest_route=\/wp\/v2\/posts\/87501\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sgbuzz.com\/index.php?rest_route=\/wp\/v2\/media\/87503"}],"wp:attachment":[{"href":"https:\/\/sgbuzz.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=87501"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sgbuzz.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=87501"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sgbuzz.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=87501"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}